NIPT False Positive Risk

What's the chance a 'high-risk' NIPT result is actually a false positive?

Test sensitivity (%)

Test specificity (%)

Base prevalence (%)

Maternal age

PPV (base)

58.25%

Adjusted prevalence

0.140%

PPV (age-adjusted)

58.25%

P(false positive | positive)

41.75%

Verdict

Strong likelihood — follow up per ACOG guidance.

About this tool

Compute the Positive Predictive Value from sensitivity, specificity, and prevalence (with age adjustment). Targets r/BabyBumps 'false positive rate of NIPT' thread.

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